Move faster – from binding to findings

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See a full picture of binding events with ease and confidence

Meet Fluidity One-M

Your toolbox to fast-track protein interaction analysis

Measure in solution

Direct measurement in solution without purification and immobilization.

Start simple

Just mix and measure, with machine learning guided assays

Break the constraints

Works for any targets and backgrounds, such as serum, plasma and cell lysate

Work faster

Get a full binding curve and K_D with a simple workflow in 25 minutes

Avoid biases

With single-use consumables. No cross-contamination

Complete the picture

Binding affinity, concentration, stoichiometry and size, all at once

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Explore our technology

Get to know Microfluidic Diffusional Sizing (MDS), the technology that drives our products. MDS gives one simple and direct measurement – protein molecular size. When binding occurs, changes in protein size are monitored and used to determine binding affinity and calibration-free concentration or binding stoichiometry.

Dive deeper

Win the race to insights

Accelerate protein interaction analysis across a wide range of research areas

Membrane protein characterization & quantification

Serum antibody concentration
& affinity

Monoclonal therapeutic antibody characterization

Affinity & stoichiometry of amyloid species

Quality control of reagents & protein activity

Organ transplant recipient immunoprofiling

What our users say

“MDS allows simultaneously determining both concentration and affinity of donor-specific antibodies under native conditions, directly in clinical samples, which is highly valuable.

MDS concentration/affinity tests have the potential to replace expensive antibody titre-determinations.

We particularly appreciate the high degree of standardisation of this approach, making it well suited for use in clinical laboratories.”

Dr Gideon Hoenger
University Hospital Basel

“We initially developed the MDS technology in our lab and have now switched to using the Fluidity One M instrument for all of our MDS and protein interaction work because it’s very robust and convenient.”

Prof. Tuomas Knowles
University of Cambridge

“MDS allowed us to obtain unique information that helped us elucidate, for the first time, the way antibody therapeutics bind to different forms of their targets.”

Prof. Sara Linse
Lund University

Trusted by your peers

Learn how MDS and Fluidity One-M support the science across the world and empower a wide range of protein interaction research.

Browse our publications >