Measuring molecular interactions can be tough. But we’ve got your back.
Start simple in less than 1 day
Your time is precious, it should be spent on exploring the insights, not getting lost among complex protocols. Get started easily and confidently with a simple mix-and-measure workflow. No training is required.
Get data delivered in 25 minutes
Fluidity One-M is built to help you move faster to insights. It takes 25 minutes to generate 24 data points, providing a full binding curve and KD value. Go grab some lunch and come back to see your publication-ready results.
Preparation
10 minutes
Transfer
3 minutes
Measurement
25 minutes
Analysis
2 minutes
See a full picture without assumptions
Affinity alone can’t tell a complete story about how proteins truly interact. Fluidity One-M provides multiple metrics to help you fully assess the intricacies of protein interactions.
Molecular size
Fluidity One-M measures molecular size (hydrodynamic radius) of a sample by evaluating its diffusion in a microfluidic chamber.
Binding affinity
The size of the protein is measured in free form and against a titration of binding partner, allowing construction of a binding curve and calculation of binding affinity (KD).
Calibration-free concentration
The concentration of active binding sites can be determined by measuring binding at different concentrations of the labelled protein.
Stoichiometry
Concentration data can also be used to determine binding stoichiometry (number of binding sites per molecule).
Measure in solution, break the constraints
Swiftly overcome the common challenges of traditional protein characterization methods and explore the behaviours of any proteins in their native environments.
No immobilization
With Fluidity One-M, you can measure interactions directly in solution without having to immobilize your proteins on a surface.
No purification
No purification is needed. Fluidity One-M can work with crude samples, saving you preparation time and simplifying the workflow.
No background constraints
Confidently tackle complex backgrounds such as serum, plasma or cell lysate that are difficult for traditional methods.
No target constraints
Analyze any targets from traditional to challenging ones, such as protein aggregates, membrane proteins, disordered proteins, and PROTACs.
What our users say
We pay attention to detail, so you can pay attention to discoveries.
No cross-contamination
Avoid cross-contamination biases while saving cost with our single-use plate-based consumables
Low maintenance
Avoid clogging, priming, or flushing because no fluidics are in the instrument
Fear of getting lost? Not with us
You are not alone on this journey. Fluidity One-M is supported by Fluidity Insight, an analytics platform and co-pilot to keep your experiment design on the right track.
Fluidity Insight supports you with machine learning guided assay development, letting you know which datapoints you can add to your existing dataset to best improve the fit quality of your experiment.
Start small. Gain big.
And move fast.
4 µL
Sample volume per data point, enabling KD determination with as little as 50 µL of sample
1-20 nm
Range for size measurement, covering peptides to multiprotein complexes and fibrillar aggregates
24 data points
Number of data points generated in one single experiment
from pM to µM
Range for affinity measurement, covering high and low affinity systems
See how Fluidity One-M accelerates real-world projects
- Highlights
- Publications
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Looking for more information?
Find out more about the instrument and our consumables, and explore a collection of articles, documents, videos and other resources to learn more about our technology and products, or contact us for more information.
Consumables
Fluidity One-M Chip-plates
Two boxes each containing eight chip-plates
These chip-plates are for use with the Fluidity One-M instrument to characterize protein interactions, including the determination of affinity (KD), size, concentration, and stoichiometry.
News & Blogs
Stay updated with the latest news, knowledge and trends in protein interaction research.
Resources
Access a library of resources about our technology and products, covering educational videos, user guides, application notes, publications and many more.