One Partner.
Complete Insight.

Tackling complex biology with an end-to-end portfolio –
from single‑cell screening to molecular characterization.

Seamlessly traverse cellular function
and molecular binding

As the home of Sphere Bio and Fluidity One‑M, we deliver an end‑to‑end portfolio for complex biology. Move seamlessly from multiplex single‑cell screening to in‑solution biophysics – reducing assumptions and accelerating confident decisions.

Move faster – from binding to findings

Meet Fluidity One-M, our toolbox to fast-track protein interaction analysis

Measure in solution

Direct measurement in solution without purification and immobilization.

Start simple

Just mix and measure, with machine learning guided assays

Break the constraints

Works for any targets and backgrounds, such as serum, plasma and cell lysate

Work faster

Get a full binding curve and KD with a simple workflow in 25 minutes

Avoid biases

With single-use consumables. No cross-contamination

Complete the picture

Binding affinity, concentration, stoichiometry and size, all at once

Cell selection, sorted

High-throughput single-cell screening powered by picodroplet microfluidic technology

Leveraging our expertise in picodroplet microfluidic technology, we offer high-throughput platforms, consumables, and reagents for single cell isolation as well as analysis in biologics discovery and development, cell engineering, synthetic biology, and more. We’ve collaborated with key opinion leaders to ensure that they are robust, proven, and will fit seamlessly into your workflows. Work small, think big with us.

Driven by cutting-edge technologies

Microfluidic Diffusional Sizing

Rapid and easy determination of hydrodynamic sizes and interactions of biomolecules in solution

Get to know Microfluidic Diffusional Sizing (MDS), the technology that drives our products. MDS gives one simple and direct measurement – protein molecular size. When binding occurs, changes in protein size are monitored and used to determine binding affinity and calibration-free concentration or binding stoichiometry.

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Picodroplet Microfluidic Technology

The core of our Cyto-Mine® platforms

Each picodroplet is used to encapsulate a cell. The chemistry of the emulsions is carefully designed to give long-term stable, biocompatible droplets with minimal leakage of molecules from the droplet, right down to small molecules such as metabolites. This provides an ultra-miniaturized test tube, containing media, reagents, and cells, that allows large-scale experiments at the single cell level.

Win the race to insights

Accelerate protein interaction analysis across a wide range of research areas

Membrane protein characterization & quantification

Serum antibody concentration
& affinity

Monoclonal therapeutic antibody characterization​

Affinity & stoichiometry of amyloid species

Quality control of reagents & protein activity

Organ transplant recipient immunoprofiling​

What our users say

“MDS allows simultaneously determining both concentration and affinity of donor-specific antibodies under native conditions, directly in clinical samples, which is highly valuable.

MDS concentration/affinity tests have the potential to replace expensive antibody titre-determinations.

We particularly appreciate the high degree of standardisation of this approach, making it well suited for use in clinical laboratories.”

Dr Gideon Hoenger
University Hospital Basel

“We initially developed the MDS technology in our lab and have now switched to using the Fluidity One M instrument for all of our MDS and protein interaction work because it’s very robust and convenient.”

Prof. Tuomas Knowles
University of Cambridge

“MDS allowed us to obtain unique information that helped us elucidate, for the first time, the way antibody therapeutics bind to different forms of their targets.”

Prof. Sara Linse
Lund University

Trusted by your peers

Learn how MDS and Fluidity One-M support the science across the world and empower a wide range of protein interaction research.

Fluidic Sciences Ltd