News and Blogs

The fuzziness of intrinsically disordered proteins Protein–protein interactions (PPIs) are fundamental to all cellular functions. The mechanism by which we understand these interactions has evolved from the early “lock and key” model [1] to the...

In this blog post we delve into the definition of GPCRs, reasons behind why elucidating GPCR structures are so important as well as why they are hard to study. Why are GPCRs important? G protein-coupled receptors (GPCRs) make up the largest family...

The stoichiometry, or relative number, of proteins in a complex is one of those aspects of bioscience that is often hard to infer or quantify. However, it is increasingly seen as more and more important in drug discovery and disease pathology. The...

Antibodies are proteins that bind with high affinity and specificity to target molecules. They are one of the most used tools in protein biology and are playing an ever-increasing role as therapeutics [1]. Some have been produced to directly...

Over the past two decades the functions and importance of intrinsically disordered proteins (IDPs) have become more widely appreciated, reflected in the persistent increase in their appearance in the peer-reviewed literature (Figure 1). This...

Affinity and avidity are an example of those pesky terms that seem interchangeable but in reality, are quite different. In this blog post we will be exploring the differences of affinity vs. avidity, and hopefully dispelling that vagueness you feel...